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	<title>Blog About Health &#38; Medicine &#187; Diabetes</title>
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		<title>NATURAL HISTORY OF TYPE 1 DIABETES: EFFECT OF INTENSIVE MANAGEMENT – THE DCCT INVESTIGATORS ABOUT HYPOGLECIMIA</title>
		<link>http://drugscentral.net/2011/06/natural-history-of-type-1-diabetes-effect-of-intensive-management-%e2%80%93-the-dcct-investigators-about-hypoglecimia</link>
		<comments>http://drugscentral.net/2011/06/natural-history-of-type-1-diabetes-effect-of-intensive-management-%e2%80%93-the-dcct-investigators-about-hypoglecimia#comments</comments>
		<pubDate>Mon, 06 Jun 2011 15:36:26 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Diabetes]]></category>

		<guid isPermaLink="false">http://drugscentral.net/?p=195</guid>
		<description><![CDATA[The DCCT investigators-concluded that intensive management of type 1 diabetes, with a goal of normal or near-normal levels of glycemia, is associated with an increased risk of severe hypoglycemia. Individualization of therapeutic goals and methods was encouraged. In particular, future development of intensive treatment methods that afford the benefits of improved glucose control with reduced [...]]]></description>
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<div id="_mcePaste">The DCCT investigators-concluded that intensive management of type 1 diabetes, with a goal of normal or near-normal levels of glycemia, is associated with an increased risk of severe hypoglycemia. Individualization of therapeutic goals and methods was encouraged. In particular, future development of intensive treatment methods that afford the benefits of improved glucose control with reduced risks of hypoglycemia was advocated.</div>
<div id="_mcePaste">Hypoglycemia unawarerfess is frequently seen in type 1 diabetics after-prolonged periods of intensive glucose regulation and recurrent hypoglycemic attacks. This issue has received extensive study. It has been postulated that in hypoglycemia-aware type 1 patients, beta-adrenergic sensitivity is increased to compensate for impaired catecholamine response. With repeated episodes of hypoglycemia, this increased sensitivity is lost. The end result is hypoglycemia unawareness with reduced catecholamine response and reduced beta-adrenergic sensitivity. Recent studies have shown that this sensitivity may be restored in type 1 diabetes by avoiding hypoglycemia with less stringent blood glucose control. Thus, in patients with hypoglycemia unawareness, it is appropriate to modify the stringent HbA1 c and plasma glucose control goals to avoid recurrent hypoglycemia and hypoglycemic unawareness.</div>
<div id="_mcePaste">*38\357\8*</div>
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		<title>THE G.I. FACTOR: THE CARBOHYDRATE/G.I. FACTOR LINK</title>
		<link>http://drugscentral.net/2009/05/the-gi-factor-the-carbohydrategi-factor-link</link>
		<comments>http://drugscentral.net/2009/05/the-gi-factor-the-carbohydrategi-factor-link#comments</comments>
		<pubDate>Fri, 08 May 2009 12:44:49 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Diabetes]]></category>

		<guid isPermaLink="false">http://drugscentral.net/2009/05/the-gi-factor-the-carbohydrategi-factor-link</guid>
		<description><![CDATA[Newer studies are revealing that the physiological responses to food (how food acts in the body) are far more complex than was previously appreciated. What is true is that different carbohydrate-containing foods do have different effects on blood sugar levels. Only in recent years have scientists begun to study the actual blood sugar responses to [...]]]></description>
			<content:encoded><![CDATA[<p><span style="font-family:Courier New; font-size:10pt">Newer studies are revealing that the physiological responses to food (how food acts in the body) are far more complex than was previously appreciated. What is true is that different carbohydrate-containing foods do have different effects on blood sugar levels.<br />
</span></p>
<p><span style="font-family:Courier New; font-size:10pt">Only in recent years have scientists begun to study the actual blood sugar responses to hundreds of different foods in real people, healthy people and people with diabetes. They gave them real foods—not solutions of sugars and starches in water. They measured the blood sugar levels at frequent intervals, for as long as two to three hours after the meal. To compare foods according to their true physiological effect on blood sugar levels, they came up with the term &#8216;glycaemic index&#8217;.<br />
</span></p>
<p><span style="font-family:Courier New; font-size:10pt">The glycaemic index (or G.I. factor as we have called it) is a ranking of foods from 0 to 100 that tells us whether a food will raise blood sugar levels dramatically, moderately, or just a little.<br />
</span></p>
<p><span style="font-family:Courier New; font-size:10pt">This research has turned some widely held beliefs upside down.<br />
</span></p>
<p><a href="http://www.exactfindrx.com/?product=actos" title="Generic Actos"><span style="font-family:Courier New; font-size:10pt">The first surprise was that many starchy foods (bread, potatoes and many types of rice) are digested and absorbed very quickly, not slowly as had always been assumed.<br />
</span></a></p>
<p><span style="font-family:Courier New; font-size:10pt">Secondly, they found that moderate amounts of most sugary foods (confectionery, ice cream etc.) did not produce dramatic rises in blood sugar as had always been thought. The truth was that foods containing sugar actually showed quite low-to-moderate blood sugar responses, lower than foods like bread.<br />
</span></p>
<p><span style="font-family:Courier New; font-size:10pt">So, it is time to forget the old distinctions that were made between starchy foods and sugary foods or simple versus complex carbohydrate. These distinctions are based on chemical analysis of the food, which does not reflect the effects of these foods in the body. The G.I. factor takes us nearer to a full understanding of how the body responds to carbohydrate foods.<br />
</span></p>
<p><span style="font-family:Courier New; font-size:10pt">The G.I. factor is a ranking of foods based on their overall effects on blood sugar levels. Blood sugar or blood glucose? Blood sugar and blood glucose mean the same thing, although the latter is technically more correct However, we use the term blood sugar in this book because It is more widely understood. &#8216;Glycaemic&#8217; refers to &#8216;blood sugar&#8217;.<br />
</span></p>
<p><span style="font-family:Courier New; font-size:10pt">*21\33\4*<br />
</span></p>
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		<title>LIVING WITH DIABETES: ISLET CELLS COULD BE USED</title>
		<link>http://drugscentral.net/2009/04/living-with-diabetes-islet-cells-could-be-used</link>
		<comments>http://drugscentral.net/2009/04/living-with-diabetes-islet-cells-could-be-used#comments</comments>
		<pubDate>Thu, 23 Apr 2009 08:43:18 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Diabetes]]></category>

		<guid isPermaLink="false">http://drugscentral.net/2009/04/living-with-diabetes-islet-cells-could-be-used</guid>
		<description><![CDATA[It is possible to separate the islet cells (which make insulin) from the gland tissue (which makes digestive juice) in the laboratory. This can be done from adult pancreases but is a difficult procedure and only a very small proportion of the adult pancreas consists of islet cells. Islet cells can be obtained from the [...]]]></description>
			<content:encoded><![CDATA[<p><span style="font-family:Courier New; font-size:10pt">It is possible to separate the islet cells (which make insulin) from the gland tissue (which makes digestive juice) in the laboratory. This can be done from adult pancreases but is a difficult procedure and only a very small proportion of the adult pancreas consists of islet cells.<br />
</span></p>
<p><span style="font-family:Courier New; font-size:10pt">Islet cells can be obtained from the pancreas of fetuses obtained in abortion, or new-born babies who die soon after birth. It has been hoped that these islet cells, which can be cultured in the laboratory, can be placed in the body of persons with diabetes and grow there to produce enough insulin to control the diabetes.<br />
</span></p>
<p><span style="font-family:Courier New; font-size:10pt">So far work in this field has been somewhat discouraging, though there is some encouragement in that the system works well in experimental animals. It is not known yet whether in the human the islet cells could grow in number and function normally after transplantation.<br />
</span></p>
<p><span style="font-family:Courier New; font-size:10pt">Tissue rejection remains a problem with islet cells as with transplantation of the whole or part of the pancreas. <a href="http://www.exactfindrx.com/?category=diabetes" title="Treating type 2 diabetes in certain patients">It is likely that this problem of tissue rejection will be solved eventually.</a> Tissue rejection refers to the process in which the body fights against strange and foreign tissues placed in the body, and thus rejects the transplant which can no longer survive.<br />
</span></p>
<p><span style="font-family:Courier New; font-size:10pt">The major problems may prove to be in the supply of islet cells and whether they can function properly when they are transplanted. There are problems in obtaining pancreas tissue from aborted fetuses &#8211; problems that are moral, ethical and practical &#8211; and these problems have not been resolved. It is not known whether islet cells will grow and function adequately when placed in a person with diabetes or whether they themselves may be damaged in the same way as the person&#8217;s own pancreas cells were damaged when he developed diabetes.<br />
</span></p>
<p><span style="font-family:Courier New; font-size:10pt">These questions are the subject of a great deal of active research in several world centers including in Australia. It may be many years before they are answered but the possibilities are very hopeful.<br />
</span></p>
<p><span style="font-family:Courier New; font-size:10pt">*77/54/5*<br />
</span></p>
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